By John G. Bartlett
Designed to supply easy access to the factors with which to struggle infectious ailment by means of concentrating on choice, right doses, bills, and negative effects of antimicrobial brokers, the 2004 notebook of Infectious affliction treatment attracts broadly from thoughts made through the facilities for affliction regulate, the clinical Letter, the yankee medical institution Formulary provider, and the AMA's Drug reviews. Tabular fabric has been up to date to incorporate all newly licensed antibiotics, in addition to new thoughts for administration.
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Extra info for 2004 Pocket Book of Infectious Disease Therapy
Regimen 1. Standard dose Gentamicin and tobramycin: 5–6 mg/kg/d (some use 4–7 mg/kg/d) Amikacin and streptomycin: 15–20 mg/kg/d 2. 5 Cg/mL Amikacin:<5 Cg/mL 3. 41 C. 5 —1–3 g q4–6h Usual usual Usual Usual 1–2 g IV q8h 1–2 g IV q 12h g q6h Ampicillin-sulbactam Renal 1 8–12 — 1–2 g q6h 1–2 g IV q8h 1–2 g IV q8h 1–2 g IVq12h Atovaquone Gut 70 70 750 mg bid susp — Usual Usual Unknown Atovaquone +proguanil Urinary 70 ? 7 ? 4 ? 25–1 g q6h Usual Usual Usual Chloroquine Renal and metabolized 48–120 ? 5–1 g q12h Cycloserine Renal 8–12 ?
25 mg/kg q24h given postdialysis on dialysis days ? 75 mg/kg/d Ketoconazole Usual regimen Usual regimen Lamivudine 25–50 mg/d dose postdialysis 25–50 mg/d Levofloxacin 500 mg, then 250 mg q48h 500 mg, then 250 mg q48h Linezolid Usual dose Usual dose Metronidazole Usual regimen Usual regimen Mezlocillin 2–3 g postdialysis then 3–4 g q12h 3 g q12h Minocycline Usual dose (some suggest reduced dose) Usual dose (some suggest reduced dose) Moxalactam 1–2 g postdialysis 1–2 g/d Moxifloxacin Usual dose Usual dose Nafcillin Usual regimen Usual regimen Netilmicin 2 mg/kg postdialysis Loading dose predialysis 3–5 mg/L dialysate* Ofloxacin 200 mg, then 100 mg q24h ?
Chloramphenicol: Use with caution with renal and/or hepatic failure; monitor serum levels to achieve levels of 5–20 :g/mL. Clindamycin: Dose reduction recommended only for severe hepatic failure. Daptomycin: No dose adjustment. Fluoroquinolones: Use standard dose except with trovafloxacin (see below). Isoniazid: Use with caution and monitor hepatic function for mild-moderate hepatic disease; acute liver disease or history of INH-associated hepatic injury is contraindication to INH. Itraconazole: Two-fold increase in half-life with cirrhosis; give with caution.