Abnormal Female Puberty: A Clinical Casebook by Heather L. Appelbaum

By Heather L. Appelbaum

Comprised solely of medical situations overlaying irregular girl puberty and its scientific administration, this concise, sensible casebook will supply clinicians in reproductive endocrinology, gynecology and pediatrics with the easiest real-world concepts to correctly diagnose and deal with many of the sorts of the situation they might stumble upon. every one bankruptcy is a case that opens with a distinct scientific presentation, through an outline of the analysis, review and administration ideas used to regard it, in addition to the case consequence and medical pearls and pitfalls. circumstances incorporated illustrate diverse factors of irregular puberty in addition to administration innovations, together with congenital anomalies, endocrine problems, problems with constitutional hold up, weight problems, consuming problems, ovarian melanoma and the impression of pharmacology, between others. Pragmatic and reader-friendly, Abnormal lady Puberty: A medical Casebook can be a great source for reproductive endocrinologists, gynecologists and pediatricians alike.

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D. L. D. L. T. L. Connor Introduction The girl with constitutional delay of puberty and growth (CDGP) represents one end of the spectrum of the normal pubertal timing and linear growth of childhood. Genetically programmed to have a slowdown of linear growth as a toddler, with subsequent bone age delay but normal childhood growth velocity, the girl with constitutional delay will by definition eventually have a normal pubertal growth spurt, normal pubertal development, and a final adult height appropriate for her family’s genetic potential, albeit at an age significantly older than her female peers.

Small, unilocular ovarian cysts of less than 1 cm in diameter in prepubertal girls are clinically insignificant, while ovarian cysts associated with GIPP are generally larger than 2 cm in diameter [34]. Management Most autonomously functioning ovarian cysts will spontaneously involute, thereby removing the estrogen production and causing the precocious puberty to regress. Surgical excision of the cyst is reserved for refractory cases, complex ovarian masses, or large cysts where there is a risk for ovarian torsion [35].

19. Jung H, Carmel P, Schwartz MS, Witkin JW, Bentele KH, Westphal M, Piatt JH, Costa ME, Cornea A, Ma YJ, Ojeda SR. Some hypothalamic hamartomas contain transforming growth factor alpha, a puberty-inducing growth factor, but not luteinizing hormone-releasing hormone neurons. J Clin Endocrinol Metab. 1999;84(12):4695–701. 20. Laue I, Comite F, Hench K, Loriaux D, Cutler CH, Pescovitz O. Precocious puberty associated with neurofibromatosis and optic gliomas. Am J Dis Child. 1985;139:1097. 21. Zacharin M.

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