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Am J Surg Pathol. 2001;25:1347–1354. 10. Horn LC, Neinel A, Handzel R, et al. Histopathology of endometrial hyperplasia and endometrial carcinoma: an update. Ann Diagn Pathol. 2007;11:297–311. 11. Lacey JV, Ioffe OB, Ronnett BM, et al. Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan. Br J Cancer. 2008;98:45–53. 12. Trimble CL, Kauderer J, Zaino R, et al. Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study.
2. Mazur MT. Endometrial hyperplasia/adenocarcinoma. A conventional approach. Ann Diagn Pathol. 2005;9:174–181. 3. Hendrickson MR, Longacre TA, Kempson RL. The uterine corpus. , eds. Sternberg’s Diagnostic Surgical Pathology. Philadelphia: Lippincott Williams & Wilkins; 2004:2435–2542. 4. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients. Cancer. 1985;56:403–412. 5. Mazur MT, Kurman RJ. Endometrial hyperplasia, endometrial intraepithelial carcinoma, and epithelial cytoplasmic change.
The nuclei of the neoplastic cells preserve their polarity in relation to the basement membrane of the epithelium, and the contour of the papillae is smooth (Fig. 4-7). 14 Secretory Variant This rare variant of endometrioid adenocarcinoma is usually seen in postmenopausal patients, although it can also occur in premenopausal patients, with or without a history of endogenous or exogenous progestational effect. Its histologic hallmark is the presence of intracytoplasmic vacuoles in most of the neoplastic cells.